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Photosensitivity is another common complication in PDT, which can last for months [206], although nowadays many approaches have been suggested for overcoming these disadvantages such as using fiber optics for more light penetration in depth tissue and application of novel PSs that induce less photosensitivity in patients

and manual observations also confirmed that these were in multiple categories or pathways (Table 1), We used a cut off of log 2 fold =1.20

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